Publications
Articles can be accessed by clicking on TOC figures.
2024
Challenges and Prospects of DNA-Encoded Library Data Interpretation
M. Wichert, L. Guasch, R. M. Franzini
Chem. Rev. in press.
Elucidating the Unconventional Binding Mode of a DNA-Encoded Library Hit Provides a Blueprint for Sirtuin 6 Inhibitor Development
W. You, A. L. Montoya, S. Dana, R. M. Franzini, C. Steegborn
ChemMedChem 2024, e202400273.
2023
Combining Pharmacophore Models Derived from DNA-Encoded Chemical Libraries with Structure-Based Exploration to Predict Tankyrase 1 Inhibitors
A.L. Montoya, M. Glavatskikh, B. J. Halverson, L. H. Yuen, H. Schuler, D. Kireev, R. M. Franzini
Eur. J. Med. Chem. 2023, 246, 114980
Orthogonal Inverse-Electron-Demand Cycloaddition Reactions Controlled by Frontier Molecular Orbital Interactions
D. Svatunek, K. Chojnacki, T. Deb, H. Eckvahl, K. N. Houk, R. M. Franzini
Org. Lett. 2023, 25, 6340.
Evaluation of the Topology Space of DNA-Encoded Libraries
W. Weigel III, A. L. Montoya, R. M. Franzini
J. Chem. Inf. Mod., 2023, 63, 4641.
2021
Mechanisms and Substituent Effects of Metal-Free Bioorthogonal Reactions
T. Deb, J. Tu, R. M. Franzini
Chem. Rev., 2021, 121, 6850.
2020
Integrating DNA-encoded Chemical Libraries with Virtual Combinatorial Library Screening: Optimizing a PARP10 Inhibitor
M. Lemke, H. Ravenscroft, N. J. Rueb, D. Kireev, D. Ferraris, R. M. Franzini
Bioorg. Med. Chem. Letts., 2020, 30, 127464.
A Stable Precursor for Bioorthogonally Removable 3-Isocyanopropyloxycarbonyl (ICPrc) Protecting Groups
J. Tu, M. Xu, R. M. Franzini
Synlett, 2020, 31, 1701-1704.
The Unique Bioorthogonal Chemistry of Isonitriles
T. Deb, R. M. Franzini
Synlett, 2020, 31, 938-944.
Isonitrile-responsive and Bioorthogonally Removable Tetrazine Protecting Groups
J. Tu, D. Svatunek, S. Parvez, H. J. Eckvahl, M. Xu, R. T. Peterson, K. N. Houk, R. M. Franzini
Chem. Sci. 2020, 11, 169-179.
2019
Tuning Isonitrile/Tetrazine Chemistry for Accelerated Deprotection and Formation of Stable Conjugates
M. Xu, T. Deb, J. Tu, R. M. Franzini
J. Org. Chem. 2019, 84, 15520-15529.
Stable, Reactive and Orthogonal Tetrazines: Dispersion Forces Promote the Cycloaddition with Isonitriles
J. Tu, D. Svatunek, S. Parvez, A. C. Liu, B. Levandowski, H. J. Eckvahl, R. T. Peterson, K. N. Houk, R. M. Franzini
Angew. Chem. Int. Engl. Ed., 2019, 58, 9043-9048.
A Focused DNA-encoded Chemical Library for the Discovery of Inhibitors of NAD+-dependent enzymes
L. H. Yuen, S. Dana, Y. Liu , S. I. Bloom, A. G. Thorsell, D. Neri, A. J. Donato, D. B. Kireev, H. Schuler, R. M. Franzini
J. Am. Chem. Soc., 2019, 141, 5169-5181.
Dissociative Bioorthogonal Reactions
J. Tu, M. Xu, R. M. Franzini
ChemBioChem, 2019, 20, 1615-1627.
2018
Bioorthogonal Removal of 3-Isocyanopropyl Groups Enables the Controlled Release of Fluorophores and Drugs in Vivo
J. Tu, M. Xu, S. Parvez, R. T. Peterson, R. M. Franzini
J. Am. Chem. Soc. 2018, 140, 8410-8414.
A DNA‐Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition
N. Favalli, S. Biendl, M. Hartmann, J. Piazzi, F. Sladojevich, S. Graslund, P. J. Brown, K. Nareoja, H. Schuler, J. Scheuermann, R. Franzini, D. Neri
ChemMedChem 2018, 13, 1303-1307.
2017
Dissociative reactions of benzonorbornadienes with tetrazines: scope of leaving groups and mechanistic insights
M. Xu, R. Galindo-Murillo, T. Cheatham, R. M. Franzini
Org. Biomol. Chem. 2017, 15, 9855-9865.
Rapid and efficient tetrazine-induced drug release from highly stable benzonorbornadiene derivatives
M. Xu, J. Tu, R. M. Franzini
Chem. Commun. 2017, 53, 6271-6274.
Stability of Oligonucleotide–Small Molecule Conjugates to DNA-Deprotection Conditions
L. H. Yuen, R. M. Franzini
Bioconjugate Chem. 2017, 28, 1076-1083.
Achievements, Challenges, and Opportunities in DNA‐Encoded Library Research: An Academic Point of View
L. H. Yuen, R. M. Franzini
ChemBioChem 2017, 18, 829-836.
2016
Chemical Space of DNA-Encoded Libraries
R. M. Franzini, C. Randolph
J. Med. Chem. 2016, 59, 6629-6644.
Automated screening for small organic ligands using DNA-encoded chemical libraries
W. Decurtins, M. Wichert, R. M. Franzini, F. Buller, M. A. Stravs, Y. Zhang, D. Neri, J. Scheuermann
Nat. Protocols, 2016, 11, 764-780.